The University of Seville´s cultural heritage collection is quite extensive. The artistic elements alone consist of more than 4,000 pieces that are comparable as far as quality and quantity to some big museums. These works, which have come together over five centuries, are currently located in various University-owned buildings. This extensive and heterogeneous artistic richness, which is closely linked to the new social and legal norms regarding heritage, has demanded that the University of Seville, with its instruments for planning, control and guardianship, make others, especially those in the University community, aware of the mentioned works and active in safeguarding them.The origin of the University of Seville was the Santa María de Jesús School, founded by archdeacon Rodrigo Fernández de Santaella in the late 1460´s. The five centuries leading to the modern University can be divided into five fundamental stages.