The origin of the University of Guyana is located at the National College decreed by the President of Gran Colombia, General Francisco de Paula Santander. This decree was issued in Bogota on October 27, 1824 and subsequently revised by the President Jose Antonio Paez in 1834. On this occasion the National School of Guayana was created in the city of Angostura in order to formalize the second-level education Orinoco province. The College began operations in 1840 in the House of Angostura Congress without Rector (just by Professor Andrés Level Eusebio, who was the son of the Rector of the College of Cumana) and thirty students. In 1842 he was appointed rector Elias Valenzuela professor who taught philosophy. In 1849 Ramon Isidro Montes who was a lawyer at the Central University became director of the school until 1854. During his stewardship the first graduates graduated in philosophy and medicine and law courses were created giving rise to it is raised to college. By 1852 Congress had decreed the chairs of law, medicine, eclesiáticas science, mathematics and philology.