The proposed creation of the UNI was presented March 25, 1995 by a Central Coordinating Committee, chaired by lawyer Lorenzo Zacarías López, then mayor of the city of.19 March 1998, the authorities carried out the first University Assembly to elect their authorities. They were elected on Abog. Lorenzo Zechariah and Ing. Hildegard González Irala as Rector and Vice Chancellor, respectively, at the time, thus starting in October the 1st stage 1998/2003 governance.
On 7 November 1996, the University Council decided to create the first two races of Degree: Electromechanical Engineering Medicine and simultaneously, creating your first two faculties, Faculty of Engineering and Faculty of Medicine. E l 18 December 1997 as Act No. 41. Commercial Engineering Career enabled, thus giving birth to the third power of the UNI, Faculty of Economics and Administrative Sciences. Later, E l University Council at its meeting on December 30, 1998 - Act No. 44, approved the creation of the Faculty of Humanities, Social Sciences and Culture Guaraní his first race, the Bachelor of Bilingualism Guaraní - Castilian.