The Autonomous University of San Luis Potosí (in Spanish: Universidad Autónoma de San Luis Potosí, UASLP) is a public university in Mexico. It is the largest university in the state of San Luis Potosí. Among other historic milestones, in 1923 UASLP was the first university in Mexico to have autonomy constitutionally granted.
On 10 January 1923, governor Rafael Nieto issued Decree No. 106, which established the University of San Luis Potosí. The academic structure of the new institution included the faculties of Medicine, Law, Chemistry and Business. It also included the Civil Hospital, the San Luis Potosí Public Library, the State Meteorological Observatory, and the normal school for training teachers. The 1923 Decree granted autonomy to the University.