The school opened in August 1962 as an extension program of the San German campus. It opened at facilities on Calle Villa, near downtown Ponce. In 1966 the school moved to more spacious facilities at the southwest corner of Calle Castillo and Calle Estrella. In the early 1980s the university started to build a new campus east of the city. In 1984 it moved to this new campus in the Mercedita sector of Barrio Vayas, Ponce. In 1992 the school became an autonomous campus of the Inter-American University system.