The University of Cincinnati (commonly referred to as Cincinnati or UC) is a comprehensive public research university in Cincinnati, in the U.S. state of Ohio, and a part of the University System of Ohio. Founded in 1819 as Cincinnati College, it is the oldest institution of higher education in Cincinnati and has an annual enrollment of over 40,000 students, making it the second largest university in Ohio and one of the 50 largest universities in the United States. In the 2010 survey by Times Higher Education (UK), the university was ranked in the top 100 universities in North America and as one of the top 200 in the world.