The Faculty of Medicine and Pharmacy of Saigon was established in 1947 in Saigon as a division of the Indochina School of Medicine in Hanoi.In 1961, it was divided into the Faculty of Medicine and Faculty of Pharmacy of Saigon. Then the Faculty of Dentistry was founded in 1964. Whereas, in the Resistance zone of the South-East of Vietnam the training of medical staff was provided by the College of Medicine established in 1965.
Following the Reunification of the country, the University of Medicine and Pharmacy, Ho Chi Minh City was founded in 1976 as an integration of the above mentioned schools and was composed of three faculties: the Faculty of Medicine, Faculty of Pharmacy and Faculty of Odonto-Stomatology. In 1994, the Faculty of Fundamental Sciences was established in order to provide the teaching of basic sciences to students of the three faculties during their first semesters of training. In 1998, the University was expanded to train auxiliary medical staff with the joining of the Faculty of Nursing and Medical Technology originated from Central Medical Technical School III.